Comparative Genetics and Evolution of Annexin A13 as the Founder Gene of Vertebrate Annexins
نویسندگان
چکیده
منابع مشابه
Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins.
Annexin A13 (ANXA13) is believed to be the original founder gene of the 12-member vertebrate annexin A family, and it has acquired an intestine-specific expression associated with a highly differentiated intracellular transport function. Molecular characterization of this subfamily in a range of vertebrate species was undertaken to assess coding region conservation, gene organization, chromosom...
متن کاملStructure-function relationship in annexin A13, the founder member of the vertebrate family of annexins.
Annexin A13 is considered the original progenitor of the 11 other members of vertebrate annexins, a superfamily of calcium/phospholipid-binding proteins. It is highly tissue-specific, being expressed only in intestinal and kidney epithelial cells. Alternative splicing generates two isoforms, both of which bind to rafts. In view of the lack of structural information supporting the physiological ...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2002
ISSN: 1537-1719,0737-4038
DOI: 10.1093/oxfordjournals.molbev.a004120